Mode of action of cyclic nucleotides

Radioimmunoassay for Cyclic Nucleotides

Sensitive and specific radioimmunoassays have been developed for cyclic adenosine 3’, 5’-monophosphate (CAMP), cyclic guanosine 3’ ,5’-monophosphate (cGMP), cyclic inosine 3’ ,5’-monophosphate (cIMP), and cyclic uridine 3’, 5’monophosphate (cUMP). These assays are based upon competition of the cyclic nucleotide with isotopically labeled cyclic nucleotide derivatives for binding sites on specifi...

CYCLIC NUCLEOTIDES CONTROL DIFFERENTIATION OF HUMAN MONOCYTES INTO EITHER HIGHLY ACCESSORY CELLS OR MACROPHAGES

Human peripheral blood monocytes have been found to undergo a transitory state of high accessory activity before they fully become macrophages. Time kinetics were done to follow this accessory potential. Studying the regulation of accessory activity, we have found that monocyte derived accessory cells (m-AC) pass through two phases of development, both of which are adversely controlled by ...

Nitric oxide and cyclic nucleotides

Spermatogenesis is a highly complicated process in which functional spermatozoa (haploid, 1n) are generated from primitive mitotic spermatogonia (diploid, 2n). This process involves the differentiation and transformation of several types of germ cells as spermatocytes and spermatids undergo meiosis and differentiation. Due to its sophistication and complexity, testis possesses intrinsic mechani...

evolution and mode of action of pulsed radiofrequency

Methods in Enzymology. Volume XXXVIII, Hormone Action, Part C, Cyclic Nucleotides

In this and the previous volume on lipids, Vol. XXXIV, Lowenstein has assembled two of the stronger recent volumes in this series. The first volume dealt with the enzymes of lipid synthesis and degradation, general analytical methods, and the preparation of substrates. This new volume is divided into the same sections, although the bulk of the book is concerned with enzymes. I think this is the...